They are betrayed by Ramsay Snow and the garrison of the Dreadfort during the battle at Winterfell, however. Theon Greyjoy notices few Karstark banners among the army commanded by Rodrik that gathers at Winterfell to expel the ironmen. Roose sends him as part of Robett Glover and Ser Helman Tallhart's force to take Duskendale. Harrion is released from captivity after the fall of Harrenhal to Lord Roose Bolton. Tyrion Lannister, the acting Hand of the King, plans to exchange Harrion Karstark and Ser Wylis Manderly for Willem Lannister, but the negotiations fail. Lord Karstark campaigns with Robb through the westerlands, driving a lance through Ser Stafford Lannister's chest at the Battle of Oxcross and raiding along the coast thereafter along with Galbart Glover. The Karstarks are one of the families with ties to House Hornwood through the female line, and thus one of the houses interested on the inheritance of the Hornwood lands after the deaths of Lord Halys Hornwood and his heir, Daryn. Rickard remains loyal and is the second man to proclaim Robb the King in the North after Lord Greatjon Umber. He is perceived by Catelyn as a man in a nightmare, gaunt and hollow-eyed in his grief. After the Battle of the Camps, Lord Karstark is seen by Catelyn praying at Riverrun's godswood with Robb and other followers of the old gods. Rickard desires vengeance for his sons, but Jaime is needed as a prisoner. Harrion is captured during this battle on the Green Fork and brought to Harrenhal. He follows Ser Gregor Clegane's charge against a double crescent of Karstark spearmen waiting behind tall oaken shields with the sigil of Karhold. Īmong others, Tyrion Lannister sees the Karstark sunburst among the enemy banners in the Green Fork. Įddard and Torrhen are two of the thirty sons of lords who ride with the Young Wolf during the battle in the Whispering Wood, where the brothers are killed by Ser Jaime Lannister. When the Stark host splits at the Twins, Rickard's heir Harrion leads the Karstark spears with Lord Bolton's infantry, while Rickard and his other sons accompany Robb with their cavalry. Catelyn Stark warns her son Robb that he cannot seem indecisive in front of men like Lord Roose Bolton and Rickard Karstark. On the march south, the Karhold men quarter in the Drunkard's Tower at Moat Cailin. The Karstark family enters the castle to pay their respects to the Starks. Led by Lord Rickard Karstark and his sons, Harrion, Eddard, and Torrhen, they bring three hundred horse and near two thousand foot to Winterfell, singing hymns and marching to the rhythm of a big drum. The Karstarks answer the summons of Robb Stark when he calls the banners of the north. ĭuring Robert's Rebellion, Lord Rickard Karstark fought alongside Lord Eddard Stark at the Battle of the Trident. These include Margaret Karstark, who was wed to Bennard Stark, the second son of Lord Benjen Stark, with whom she had three sons Alys Karstark, who was wed to Lord Brandon Stark, with whom she had three children And Lysara Karstark, who was wed to Alys's grandson Artos Stark, whom she gave two sons. Over the centuries, several Karstarks have wed Starks. The castle he built near the Grey Cliffs was named Karl's Hold, but that soon became Karhold, and over the centuries the Karhold Starks became Karstarks. Possibly around 700 BC, Karlon put down a rebel lord and was granted lands for his valor. The Karstarks descend from Karlon Stark, a younger son of Winterfell. Karstark warhorns sound deep and mournful. Karstark soldiers wear black iron halfhelms, mail hauberks or shirts of sewn rings, and heavy boots. Karstarks and their men wear thick cloaks made of the pelts of seals, bears, and wolves, or black woolen cloaks patterned with the white sunburst. Lord Rickard Karstark and his daughter, Alys, have long, narrow faces. Karstarks are big, fierce men, bearded and long-haired, with brown hair and blue-grey eyes.
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Movies on a Video DVD are organized into titles which are logically separate movies. If you press the Play button when selecting multiple files, the first selected file will be played.Īrrange the files in the desired order and title To play a file, select the desired file and either click the "Play" button at the bottom of the main interface, or select File -> Play from the menu. If you are not already running Express Burn it will be started automatically and an icon will appear in the system tray. Similarly if you drag and drop the file onto the Express Burn desktop icon it will be added to the disc. You may also add files by dragging and dropping a video file onto the main filelist window. To remove all the files, select the option Remove All from the file menu, or press Ctrl + Delete.ĭragging and Dropping and the System Tray To select multiple files at once, press the Ctrl key and left-click on the files you want to select. Once your files have been added, if you wish to remove any of them, simply select the files and either click the "Remove" button, or select File ->Remove from the menu. You may need to select 'All Files' to see the particular file. Many come preinstalled with Windows so please try loading the file. Many other formats can also be handled but they require the installation of DirectShow codecs. Additionally some formats need to be decoded to be added and on slower computers this can take a minute or two. If an internet connection is not available they can be downloaded separately from the NCH website and then installed on the PC in question. Some of these formats will automatically download a plugin to decode the selected format. A Browse window will open and from here you can locate, view and select the following types of video file formats: To add your video files to the DVD click the "Add File" or "Add Folder" button or go to the menu item File -> Add. Additionally you can click on the New disc button on the toolbar, or use This disc menu, disc Type and select a data type. The Video DVD type can be selected by using the toolbar (the row of icons at the top of the main window), selecting the 'Video' tab, and selecting 'Video DVD' button. Arrange the files in the desired order and title (optional).Select the disc compilation as a Video DVD. The process to create a DVD playable on a home DVD player Whether you’re an aspiring filmmaker, YouTube content creator or just want to make home videos, VideoPad is a great tool to have in your video-editing arsenal.Video Tab - How to Create a Video DVD Video DVD Overall, VideoPad is an excellent video editing software that can help you create professional-grade videos that you can be proud to share and keep for life. Finally, you can share your videos with your family and friends by burning them to DVD or HD DVDs or uploading them directly to YouTube - saving your login credentials in VideoPad. 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In 1980 he went to Paine Webber's Jackon Curtis arm as a vice president in credit research and fixed income investment strategy. After Mitchell Hutchins was acquired by Paine Webber in 1977 he left with his trading group to Scandinavian Securities, where he worked ultimately as an assistant vice president. He was also awarded the Chartered Financial Analyst designation in 1982.įridson interviewed with Mitchell Hutchins and accepted a position as an electric utility bond trader in 1976. cum laude in history from Harvard University in 1974, and as a result of gaining entrepreneurial work experience with Southwestern Advantage selling books door-to-door during college, was able to attend Harvard Business School the following semester, eventually graduating in 1976 with an MBA. He lives on Manhattan's Upper West Side with his wife, Elaine Sisman.įridson earned a B.A. Fridson has been referred to as the "dean of high yield debt." 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Professor of Medicine Chair, Department of Breast Medical Oncology The University of Texas MD Anderson Cancer Centerįor more news on cancer updates, research and education, don’t forget to subscribe to CURE®’s newsletters here. In the future, more and more diseases will be managed in a more timely, precise manner with these technologies. “Over and over again, we’ve seen examples of how MRD is the best predictor for outcome and (how) it can help us know when to increase or decrease or change therapies.” “ really the future for guiding the very best therapies,” one doctor told CURE. In this special issue of CURE dedicated to issues facing patients with leukemia and lymphoma, we take a look at the history of MRD testing, talk with experts about its benefits for patients during their cancer journey and discuss how this technique may benefit more patients in the future. As our knowledge has grown regarding mutations in other hematological cancers that are being targeted by a growing array of drugs, MRD assays can detect not only relapse at its earliest stage but also what new mutations are evolving that lead to resistance and can be addressed by switching to the appropriate new drug. It became very useful when newer drugs became available that target the abnormal growth-promoting enzyme (kinase) encoded by this mutation. MRD testing began among patients with chronic myeloid leukemia, a disease that lends itself to gauging MRD because it is driven by a specific genetic mutation, the BCR-ABL fusion, which is part of the Philadelphia chromosome that can be viewed under a microscope. If one or more mutations of the tumor are known, these assays for tumor-specific RNA or DNA are ultrasensitive. That is because DNA is made of two chains of complementary base pairs, and these can be multiplied and expanded either naturally (when cells divide) or artificially in a test tube using a process called polymerase chain reaction that uses some of the enzymes that are required in nature. It was pretty clear then that the key to detecting very small amounts of tumor revolved around the tumor’s DNA. The diagnosis was mainly based on endoscopically obtained biopsies.It's been more than 20 years since treatment for patients with leukemia led the way in the development of testing for minimal residual disease, also referred to as measurable residual disease (MRD). Gastrointestinal GVHD and infectious colitis accounted for the majority of gastrointestinal complications after allogeneic stem cell transplantation in our patient population. Diagnostic procedures revealed in decreasing order: GVHD (62%), gastritis/esophagitis (19%), cytomegalovirus (CMV) enteritis (11%), bacterial enteritis (6%), and toxic mucosal damage (2%). Between January 1996 and September 2001, we analyzed 42 consecutive patients who had been admitted at our institution for gastrointestinal complaints after allogeneic stem cell transplantation for hematologic diseases. The study was designed prospectively with consecutive patients and performed at our institution in a clinical stem cell transplantation setting. The diagnostic procedure for this study included physical exam, stool cultures, endoscopy with biopsies, and abdominal computed tomography (CT). The clinical presentation of each disease is nonspecific. Their main causes are gastrointestinal graft-versus-host disease (GVHD), infections, toxicity, or preexisting gastrointestinal diseases. This treatment causes substantial toxicity, and the procedure is therefore restricted to patients younger than 60 years without co-morbidity. Maximal tolerable chemoradiotherapy doses are given as part of the conditioning-regimen. Upper and lower gastrointestinal symptoms are major and serious complications after stem cell transplantation. Background: Several haematological malignancies can be cured using allogeneic stem cell transplantation (SCT). |
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